PS1017 MICRO RNA SIGNATURE OF ONCOGENIC MUSASHI RNA BINDING PROTEINS MSI1 AND MSI2
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چکیده
منابع مشابه
Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis
Characterizing the mechanisms underlying follicle development in the ovary is crucial to understanding female fertility and is an area of increasing research interest. The RNA binding protein Musashi is essential for post-transcriptional regulation of oocyte maturation in Xenopus and is expressed during ovarian development in Drosophila. In mammals Musashi is important for spermatogenesis and m...
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The Musashi family is an evolutionarily conserved group of RNA-binding proteins. In mammal, two members of the group, Msi1 and Msi2, have been identified to date. Msi1 is considered to play roles in maintaining the stem cell status (stemness) of neural stem/progenitor cells in adults and in the development of central nervous system through translational regulation of its target mRNAs, which enc...
متن کاملHuman oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket
RNA-binding protein Musashi-2 (MSI2) is a key regulator in stem cells, it is over-expressed in a variety of cancers and its higher expression is associated with poor prognosis. Like Musashi-1, it contains two N-terminal RRMs (RNA-recognition Motifs, also called RBDs (RNA-binding Domains)), RRM1 and RRM2, which mediate the binding to their target mRNAs. Previous studies have obtained the three-d...
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1 All articles published in this journal are protected by copyright. 2014 – POST-TRANSCRIPTIONAL REGULATION OF AML PROPAGATION BY ONCOGENIC RNA BINDING PROTEINS Takahiro Ito, Ayuna Hattori 1 1 University of Georgia Acute myelogenous leukemia is characterized by uncontrolled propagation of abnormal myeloid cells with a limited capacity to differentiate into mature cells. Recent studies have show...
متن کاملThe Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.
Members of the Msi family of RNA-binding proteins have recently emerged as potent oncoproteins in a range of malignancies. MSI2 is highly expressed in hematopoietic cancers, where it is required for disease maintenance. In contrast to the hematopoietic system, colorectal cancers can express both Msi family members, MSI1 and MSI2. Here, we demonstrate that, in the intestinal epithelium, Msi1 and...
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ژورنال
عنوان ژورنال: HemaSphere
سال: 2019
ISSN: 2572-9241
DOI: 10.1097/01.hs9.0000562364.92047.c1